The Top 5 Liquid Probiotic Supplements of 2022

Probiotic supplements have been linked to some health benefits. But while research on probiotics has increased significantly over the past 20 years, researchers are still learning about probiotics and the health effects of probiotic supplements.


Probiotics are live microorganisms (e.g., bacteria) that are either the same as or similar to microorganisms found naturally in the human body and may be beneficial to health.

If you picture the human body as a “host” for bacteria and other microorganisms, you might have a better understanding of probiotics. The body, especially the lower gastrointestinal tract (the gut), contains a complex and diverse community of bacteria.

Although we tend to think of bacteria as harmful “germs,” many bacteria actually help the body function properly.

Probiotic supplements have been linked to some health benefits. But while research on probiotics has increased significantly over the past 20 years, researchers are still learning about probiotics and the health effects of probiotic supplements.


*Sources used for research purposes. is not affiliated with these sites.


Health Benefits of Probiotics


Probiotics help balance the friendly bacteria in your digestive system. When the digestive system has an imbalance in bacteria, it means there’s too much bad and not enough good. This may cause digestive issues, mental health issues, obesity, allergies, and other health issues, according to a study from


Irritable bowel syndrome (IBS) is not the result of a known organic factor, and is characterized by abdominal pain, unpredictable bowel movements, and bloating. A number of different causes have been cited, including environmental, physical, and mental stress. Adding probiotics to a health regimen or diet is shown to decrease the severity and frequency of IBS. Particularly, the strain called Bifidobacterium Infantis appears to be the most successful in trials to this point. [2] [3]


Probiotics contain bacteria that are effective in lowering total and LDL (bad) cholesterol. Probiotic bacteria absorb fiber from the intestines and as a result, they generate propionic acid. This particular acid has the ability to reduce the production of cholesterol by the liver. [11]


Diarrhea is on the other extreme of digestive issues, and studies show that probiotics can also help regulate the intestinal processes to decrease diarrhea. This uncomfortable affliction can be labeled as antibiotic-associated diarrhea (AAD), acute infectious diarrhea, or Clostridium difficile disease (CDD), a condition also related to the use of antibiotics. Antibiotics can be very damaging to your intestinal processes, frequently resulting in AAD or CDD. By replenishing the good bacteria eliminated by the antibiotics with probiotics in your diet, it is possible to decrease or eliminate chronic or individual episodes of diarrhea. [4]


By consuming probiotics and actively working to maintain the balance of good and bad bacteria within your gastrointestinal system, you can actually improve the strength and efficiency of your immune system. Probiotic bacteria can inhibit the reproduction and survival of harmful pathogens in the gut, and they can also regulate the number of antibodies present in the intestines. This, in turn, leads to a stronger immune system that is better suited and prepared to fight off disease and illness. Autoimmune disorders like rheumatoid arthritis, Crohn’s Disease, and ulcerative colitis are more common when the levels of good and bad bacteria are imbalanced, so probiotics can help regulate intestinal homeostasis, and even save your life. [13]


Gut health is linked to skin health. When the gut flora is in balance, the body is able to absorb nutrients and eliminate toxins. This helps prevent chronic inflammation, which causes acne and other skin problems.

family probiotics benefits


Choosing the best probiotic can leave even the most knowledgeable of us utterly confused. Probiotics come in a variety of forms and may contain many different microbial strains, as well as a range of additional ingredients. Their shelf life, directions for use and storage guidelines may also be vastly different. As a result, it is relatively easy to pick a probiotic supplement that may not be aligned with your needs and preferences.

To help you navigate this increasingly complex world, our team has created a complete guide to the best liquid probiotic supplements. Here, we’ve covered every important aspect to consider, including type and number of bacterial strains, form, and manufacturing processes. And to give you the most thorough reviews, we have personally tried and tested multiple probiotics on the market. Still, it’s best to consult your doctor before making a final decision.


CFU stands for colony-forming unit, which simply refers to the number of live and active micro-organisms that can be found in each serving of the probiotic you are taking.


Once probiotics make their way to your gut, they begin to feed off prebiotics, a fiber-based form of food needed to help them survive, grow and populate. 


Once probiotics make their way to your gut, they begin to feed off prebiotics, a fiber-based form of food needed to help them survive, grow and populate. 


Pay attention to how your probiotics should be stored. Generally, keep them refrigerated. Heat can kill off microorganisms in probiotics if not stored correctly.



Probiotics may contain a variety of microorganisms. The most common are bacteria that belong to groups called Lactobacillus and Bifidobacterium. Other bacteria may also be used as probiotics, and so may yeasts such as Saccharomyces boulardii.

Different types of probiotics may have different effects. For example, if a specific kind of Lactobacillus helps prevent an illness, that doesn’t necessarily mean that another kind of Lactobacillus or any of the Bifidobacterium probiotics would do the same thing.

Top Probiotic Strains


L. Salivarius

L. salivarius is present in the colon, small intestines, vagina and mouth. It is generally taken in supplement form. As the main bacteria in our mouth, it is important for maintaining dental hygiene. It also plays a role in preventing intestinal diseases and supporting the immune system. 


Lactobacillus gasseri is a strain of Lactobacillus, a beneficial bacteria found in the digestive and urinary tracts. This strain of probiotics offers several benefits. It helps to reduce inflammation, improve immune functioning, and aid digestion.

lactobacillus rhamnosus

One of the most effective strains for combating antibiotic-associated diarrhea and traveler’s diarrhea. Lives in the intestines, and fights infections both in the gut and urinary tract. Assists in dairy digestion and lactose intolerance.

B. Lactis

This probiotic strain is another multi-talented ensemble member that may help support both digestive health and immune function. B. lactis comes from milk and is often found in the gut. It helps in fighting tumors, improving digestion, and boosting immune function.


Predominantly live in the large intestine and vagina, and adhere themselves to the walls of each, thus preventing bad bacteria from colonizing. B. Bifidum also produces substances that lower the pH of their environment so bad bacteria cannot thrive, and enhances assimilation of minerals.

lactobacillus acidophilus

Most commonly used probiotic. Lives in the mouth, intestines (maintains integrity of the wall of the small intestine, aiding nutrient absorption and supporting immunity) and vagina (adheres to the walls of the vagina and urinary system where it can fight infection). 




Probiotic strains serve different purposes in the body, so it’s important to choose a probiotic supplement that features a variety of robust strains. Most probiotics feature only one or two strains — far too few to be effective.

We recommend looking for a supplement with at least 9 unique strains for a more comprehensive approach to overall health and immune function. 



Probiotics requiring refrigeration can be damaged or killed off during shipping.

They may also be unable to survive the hot, acidic environment of our gut. We therefore suggest choosing a probiotic that is shelf-stable and does need to be stored in the refrigerator.  



Probiotics provide many health benefits, but whether or not they can perform those functions depends largely on if they can successfully bypass your stomach acid, which is very powerful, and make it to your small intestine where they can colonize and grow. 

5 Best Liquid Probiotics

Get Them Now

MaryRuth Organic Liquid Probiotic - $23.95
MaryRuth Liquid Probiotic

Product Name: MaryRuth Organics

Product Description: Mary Ruth’s Organics liquid probiotic is part of their well known line of natural supplements. Their goal is to create wholesome supplements that are safe and effective in improving one’s overall health. Their products contain non-GMO, plant-based, and vegan ingredients with the fewest amounts of allergens possible. This probiotic is formulated to help support a healthy microbiome and digestive tract with a blend of 12 probiotic strains. Certified USDA Organic and Vegan.

Brand: MaryRuth Organics

Offer price: $23.95

Availability: InStock

  • Effectiveness
  • Flavor
  • Value for Money

Why We Chose It

MaryRuth’s Liquid Probiotic is one of Amazon’s best sellers and it comes with a recognizable and respected brand. It is vegan, non-GMO, and USDA Certified Organic. Their probiotic is formulated to help support a healthy microbiome and digestive tract with a blend of 12 probiotic strains.

MaryRuth’s Liquid Probiotic is sugar free and free of common allergens like dairy, nuts, gluten, wheat, soy, and more. Plus, it’s shelf stable. While refrigeration is not required, they suggest refrigeration after opening to maintain freshness. It is formulated to be safe for both adults and kids. Each bottle contains 20 servings (2 fl oz bottle). The wide range of beneficial properties and the amount of beneficial bacteria make this one of the best probiotics currently on the market.


  • Lactobacillus acidophilus, L. rhamnosus, L. salivarius, L. casei, L. plantarum, Lactococcus lactis, Streptococcus thermophilus, Bifidobacterium bifidum, B. lactis, B. infantis, B. breve, B. longum
Serving Size: 3 ml Servings per Container: 20 Days supply: 20-day supply


  • Shelf stable
  • Well known for their long line of natural supplements
  • Free of most food allergens, GMOs, artificial sweeteners and colors
  • Gluten Free, Dairy Free, 100% plant based


  • Price
  • Some customers complained of constipation and upset stomach after taking it
  • It contains concentrations of grass, which can cause allergy reactions
Healthy Genetics Probiotic - $17.95

Product Name: Healthy Genetics Liquid Probiotic

Product Description: Healthy Genetics Liquid Probiotics is safe for the entire family. It contains organic Prebiotic + 12 probiotic strains with Ginger Root. Their family Probiotic contains organic prebiotics and natural vegan probiotics to support digestive health, intestinal support & immune system. Their formula is specially designed for the entire family's health needs.

Brand: Healthy Genetics

Offer price: $13.95 - $18.95

Availability: InStock

  • Effectiveness
  • Flavor
  • Value for Money

Why We Chose It

Healthy Genetics Liquid Probiotic drops is a high quality daily supplement made for the entire family. It has organic prebiotic plus 12 probiotic strains plus ginger root. No fillers, additives or unhealthy ingredients.

The addition of ginger root increases the efficacy of the probiotics by providing antioxidants that may help with bloating, inflammation and digestion.

They are made without dairy or glutten, plus it is vegan and and non-GMO.  Shoppers rave about their quality and value, with many citing digestive improvement after taking it daily. 

STRAINS: B-Breve B-Lactis Streptococcus-Thermophilus L-Plantarum L-Salivarius Lactobacillus Acidophilus L-Rhamnosus L-Casei Lactococcus-Lactis Bifidobacterium Bifidum B-Infantis B-Longum plus prebiotic and ginger root.

A wide range of products is available on their Amazon store, including Iodine, Acid Fulvic, Vitamin C, Chlorophyll and both women’s and kids’ probiotics.


  • Budget-friendly – regular sales for $12.99
  • Safe for Men, Women and Kids
  • Offers 3 variations of Liquid Probiotics: 1 for Kids and Toddlers, 1 for the entire Family and one especifically for Women
  • Shelf stable
  • Stomach acid protection


  • Sometimes low stock due to high demand
LiviaOne Daily Liquid Probiotics - $58.96

Product Name: Organic LiviaOne Probiotics

Product Description: Go Healthy Probiotics for Women, Men, Teens Digestive & Immune Health -Organic Unflavored Liquid - 40 Servings LiviaOne™ Daily Liquid Probiotics provides the vital balance needed for optimal health. It aids the gut flora in your digestive system to breakdown and absorb food and nutrients the body needs. LiviaOne™ Daily Liquid Probiotics 4 oz Dropper - Same amazing liquid probiotics as the 2 oz bottle in a larger size.

Brand: Livia Global Inc.

Offer price: $21.56

Currency: Dollar

Availability: InStock

  • Effectiveness
  • Flavor
  • Value for Money

Why We Chose It

Go Healthy Probiotics for Women, Men, Teens Digestive & Immune Health – Organic Unflavored Liquid 

LiviaOne™  Daily Liquid Probiotics is a USDA-Certified Organic Probiotic with a 12-strain proprietary blend for men and women. It supports the gut flora in your digestive system to break down and absorb food and nutrients the body needs. 

As it doesn’t require refrigeration, it’s a good option if you frequently travel or prefer not to worry about storing your probiotic supplement in the fridge.

They are formulated to super activate their natural bio-production of beneficial substances that support and super boost the immune system against infective agents like yeast overgrowth, viral and bad bacteria components, mold and fungus.* 

Strains: Lactobacillus-Acidophilus, L.Rhamnosus, L.Salivarius, L.Casei, L.Plantarum, Lactococcus Lactis, Streptococcus Thermophilus, Bifidobacterium Bifidum, B.Lactis, B.Infantis, B.Breve, B.Longum

Serving Size: 3 ml Servings per Container: 17 Days supply: 17-day supply


  • USDA Certified Organic
  • No refrigeration required
  • Natural – No Additives – No Preservatives
  • Non-Dairy – Allergen Free


  • Only 17-day supply
  • Price
Wellements Organic Liquid Probiotic - $49.99

Product Name: Wellements Organic Liquid Probiotic

Product Description: Wellements Organic Liquid Probiotic for kids. It helps eases baby's stomach discomfort. It also provides digestive and immune support. They are certified-organic ingredients to safely ease occasional stomach discomfort and gas, those not-so-fun feelings often associated with colic, fussiness, and hiccups, with probiotics to help promote digestive and immune health. Recommended for All Ages: Newborn+ Use as an everyday probiotic supplement or just as Gripe Water, anytime your baby is fussy.

Brand: Wellements

Offer price: $24.99

Availability: InStock

  • Effectiveness
  • Flavor
  • Value for Money

Why We Chose It

Choosing – and trusting supplements for your kids can be a daunting task.  Wellements claim to be chemical, preservative and paraben-free; Their formula contains certified ingredients to ensure purity and safety and is also free of gluten, dairy, soy and alcohol.

The  promote digestive and immune health while helping to relieve your little one’s occasional stomach discomfort and gas. * Use as an everyday probiotic supplement or anytime you have a fussy baby!

Pediatrician recommended and certified USDA Organic, Wellements Organic Probiotic Gripe Water is made without artificial ingredients so it is safe, fast and effective. Add packet of probiotics to Organic Gripe Water and shake well before each use. Some sediment is normal. Organic Probiotic Gripe Water may be taken directly using the dispenser provided up to 6 times in a 24-hour period. Wash and dry dispenser thoroughly after each use. For best results administer daily. Wellement’s promise is to provide products that are safe, natural and effective. All of our products are made with simple, natural and organic ingredients, leaving out all of the unnecessary preservatives, chemicals and additives. We know that a healthy foundation makes for a healthy life, and that’s why we believe in wellness from the beginning, naturally. Simply A Better Tomorrow! *This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.


  • Free From: Gluten, Dairy, Soy, Dyes, Parabens, Artificial Colors, Artificial Flavors, and Preservatives
  • Certified organic, preservative-free products without the use of plastic bottles.


  • For babies only

Explore Other Top Sellers

20 Probiotic Strains

Probiotic for Women, Men and Kids

Flora Biome – Live Probiotic, Prebiotic & Postbiotic

Price: $45.95

10 Probiotic Strains (+19 herbs)

Probiotic for Women, Men and Kids

Culturelle Baby Immune + Digestive Support Probiotic & Vitamin D

Price: 25.87

12 Probiotic Strains

For Babies, Infants & Newborns 0-12 Months


High Quality Ingredients

We included products that are made with high quality ingredients and are free from fillers, preservatives, and artificial ingredients.

Clean Formulas

We carefully critiqued and curated supplements with premium active ingredients and the fewest number of “other ingredients” since less is more on that front.


We vetted and curated probiotic formulas that include meaningful levels of high-quality, clinically-studied strains that are designed to support targeted health areas and overall well-being.

Personal Needs

Whether you need a specific probiotic strain or follow a gluten-free diet, we included options to suit a variety of needs and preferences.

Frequently Asked Questions


Talk to your health care provider before starting a probiotic. People with very weak immune systems, such as those undergoing chemotherapy, should not take probiotics due to risk of infection. Your provider or a nutritionist can help identify a probiotic containing the bacteria strain based on the condition you wish to address.


Most probiotics are safe for pregnant and breastfeeding women. However, don’t take any supplements without talking to your doctor.


In general, everyone — children and adults — should check with their physician, pediatrician, or healthcare professional before beginning any new wellness supplement to make sure the supplement is suitable for their health.


While not necessary, most information suggests getting bloodwork done prior to starting a new supplement regimen to establish a baseline before further tests.


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